| 1. | The cold agglutinin detected is of anti-i specificity.
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| 2. | This is the case in both cold agglutinin disease and cold paroxysmal hematuria.
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| 3. | Individuals with cold agglutinin disease present with signs and symptoms of hemolytic anemia.
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| 4. | There are also reports of eculizumab being used to treat cold agglutinin disease.
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| 5. | Cold agglutinins, or cold autoantibodies, occur naturally in nearly all individuals.
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| 6. | In individuals that have cold agglutinin disease, the lifespan of erythrocytes is shortened.
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| 7. | In chronic cold agglutinin disease, the patient is more symptomatic during the colder months.
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| 8. | Rheumatoid factor, cryoglobulins, direct antiglobulin test and cold agglutinin titre results can be positive.
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| 9. | This is seen in Waldenstr�m's macroglobulinemia, cold agglutinin disease and Infection with Mycoplasma Pneumonia.
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| 10. | Tests revealed no structural heart defects, and after some deliberations the possibility of cold agglutinin disease is raised.
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